Sakura would initially be shocked and scared when Orochimaru's snake form coils around her. However, she is not one to give up easily. She could quickly assess the situation and remember all her training. Instead of using brute force right away, she might use her chakra control to create a shield around herself. This would prevent Orochimaru from squeezing her too tightly. Then, she could try to use her knowledge of poisons (as she has some understanding of medical substances) to see if there's a way to affect Orochimaru's snake form. She might also start to analyze Orochimaru's motives. Is he after her chakra? Or is there something else? By thinking clearly, she can come up with a more effective strategy to deal with the situation.
Sakura could react with fear at first. After all, Orochimaru is a very dangerous and unpredictable character. But then she might gather her courage and try to use her strength to break free. She could use her punches, which are quite powerful, to hit Orochimaru's snake body.
Sakura might try to use her medical knowledge. Since Orochimaru is often involved in strange experiments, she could look for a weak point in his snake form that she can target with her medical skills. Maybe she can find a pressure point or something similar to paralyze the snake. Also, she could try to communicate with Orochimaru, using her intelligence to reason with him and convince him to let her go.
One possible fanfiction could be that Orochimaru in his snake form slithers around Sakura while she is in a forest training. Sakura, being the strong - willed ninja she is, doesn't show fear but instead tries to analyze Orochimaru's motives. She might be on a mission to retrieve some important information related to Orochimaru's experiments, and this encounter is an unexpected turn. As Orochimaru coils around her, she uses her medical ninjutsu knowledge to try and find a weak point in his snake form.
One plot idea could be that Orochimaru, in his snake form, coils around Sakura while she's on a mission alone. She manages to use her medical ninjutsu skills to fend him off. Another could be a scenario where Orochimaru is actually protecting Sakura from other threats while coiling around her in a strange, yet protective way. Maybe there's a curse on Sakura and Orochimaru's coiling is the only way to suppress it for a while.
The plot could involve Orochimaru using his snake form to trap Sakura as part of a test. He wants to see how she will react under pressure. Sakura, being resourceful, uses her surroundings to her advantage. She might break a nearby branch and use it as a weapon against the snake form. This could lead to a series of exchanges where Orochimaru is impressed by Sakura's tenacity and starts to have second thoughts about his initial intentions towards her.
One way is that the snake jutsu could be used to explore the hidden secrets of the coiling sakura. Snakes are often associated with mystery and the unknown, so they could slither through the branches and leaves of the sakura to uncover something special.
Naruto would be extremely angry and would rush to save her without a second thought. He would likely use his new jutsu and all of his strength to break into Orochimaru's lair. Sasuke, on the other hand, would be more calculated. He might gather information first and then make a strategic move. Kakashi would probably try to calm Naruto down and form a proper rescue plan, using his intelligence and experience.
Sakura would probably be horrified. She knows Orochimaru's reputation for being cruel and power - hungry. She would immediately reject any offer from him and get ready to fight if necessary. After all, she has grown into a strong kunoichi and won't be easily intimidated.
She could also pretend to cooperate with Orochimaru at first. Gain his trust a little bit and then when he least expects it, make her move. Maybe she could ask Orochimaru for some tools or access to certain areas under the pretense of helping him with his work, but in reality, she is setting up her escape.
Sakura can resist Orochimaru's influence through her strong will. She has always been a determined character in the Naruto series. Her love for her friends and her village could serve as a powerful motivation to not give in to Orochimaru. She could also use her medical ninjutsu skills. Maybe she could develop a way to counteract any mind - altering substances or jutsu that Orochimaru uses on her. Another way is by relying on her own combat skills. If she can keep Orochimaru at bay physically, she has a better chance of avoiding his psychological and physical manipulations.
One possible fanfiction could be that Deidara uses his clay snake to coil around Sakura during a battle. The snake might be infused with his explosive art, and Sakura has to use her strength and medical ninjutsu knowledge to break free. Maybe she first tries to use her brute force, but realizes it's not enough. So she then uses her chakra control skills to disrupt the clay's structure from within, ultimately escaping the coiling snake.
Shikamaru, being the intelligent strategist, would analyze the situation carefully. He would consider all the possible moves Orochimaru could make and try to anticipate his next actions. He might also try to figure out Orochimaru's motives for taking Sakura hostage in the first place.