Rory, being Amy's husband in some timelines, would be extremely conflicted. He loves Amy deeply, so he'd want to support her, but at the same time, he'd be heartbroken. River would probably approach the situation with her usual calm and collected manner. She might see it as just another strange event in the Doctor's long life. Their other friends would likely be confused at first. Some might be judgmental, while others would try to look at the positive side and offer practical help like finding a safe place for Amy to have the baby.
Rory would be a mix of emotions. He'd be worried about Amy, but also feel a bit left out since she's having a baby with the Doctor. River might be more understanding, given her complex relationship with the Doctor. She could offer some advice based on her own experiences with time - travel and family. The other friends like Craig might be shocked but also try to support them in their own bumbling, human way.
Tails would probably be very helpful. He'd use his intelligence to make sure Amy has a comfortable pregnancy, like creating special devices for her. Knuckles might be a bit awkward at first but would ultimately be very protective. He'd stand guard to make sure no harm comes to Amy and the unborn baby.
Sonic would probably be very confused at first. He might mistake Tails in Amy's body for the real Amy and be really surprised by her different behavior. Knuckles would likely be suspicious and keep asking questions. Cream might be worried about her friends and try to help them figure out what happened. Big the Cat probably wouldn't notice much difference at all, just going about his normal fishing routine.
Their friends' reactions would vary. Tails would be enthusiastic and start thinking of all the ways he could help. He could create little gadgets for the baby, like a mini - sonic - speed - training - device when it gets older. Knuckles would be more of a protector. He'd see it as his duty to make sure the baby is safe, especially since Sonic is his friend. Rouge would be the fun auntie type. She'd bring stylish baby clothes and tell the baby all kinds of exciting stories from her travels. And the Chaotix might be a bit clumsy but well - intentioned in their attempts to interact with the baby.
Their friends would be really excited. Tails would probably be the first one to offer his help. He could use his mechanical skills to build baby - friendly gadgets. Knuckles would be a bit more gruff but still happy. He might offer to train the baby in self - defense when it grows up. Cream and Cheese would bring little presents for the baby, like cute toys or delicious Chao fruits.
Naruto would probably be super excited and offer all kinds of help. He might bring over some of Hinata's home - cooked meals for Ino. Sakura would be very practical, offering her medical expertise and making sure Ino is having regular check - ups. Shikamaru would be more laid - back but still offer some sage advice about the responsibilities of parenthood.
Elena might be a bit shocked at first but then would be very supportive. She would offer her own experiences and advice, even if they are from a human perspective. Bonnie could be worried about the magical implications of a vampire pregnancy and offer to use her magic to keep an eye on the baby's development.
Their friends might be initially shocked. Some might be overjoyed and offer immediate support. For example, those who are close to them would probably start planning baby showers and getting gifts. However, there could be some friends who are worried about how this will change their group dynamic.
Sakura would probably be shocked at first, but then she'd be supportive. She might offer her medical skills to help with Tenten's pregnancy. Shikamaru would likely think it's a troublesome situation but would also offer his strategic advice on how to handle things. Kakashi would be his usual calm self and give them some wise words about responsibility and family.
If we consider Percy as one of their friends, he might be a bit protective. He could offer to help with any potential threats that might come their way because of the pregnancy. Annabeth, on the other hand, would probably be very organized in her support. She could help Reyna and Jason plan for the future, like making sure they have proper financial arrangements and a suitable living space for the baby. Some of their more light - hearted friends might make jokes about how their lives are going to change completely, but all in good fun.
Gohan would be really surprised, but being the kind - hearted person he is, he would try to understand and help out. He could offer to train with them in a more gentle way to keep them fit during the pregnancy. Piccolo would be more of a silent observer, but still be there in case of any threats.