When Naruto becomes Hinata, his relationship with Naruto's friends would be complex. He'd be in a female body and have to navigate through the different expectations society has for Hinata. His relationship with Kiba and Shino, Hinata's former teammates, would become more personal as he now shares Hinata's memories and feelings. And his relationship with Naruto's old crush, Sakura, would be a bit awkward as he tries to act like Hinata.
Suppose Naruto becomes Jiraiya. His relationship with Tsunade would become a lot more interesting. He'd be in the shoes of Jiraiya, who had a long - standing, unrequited love for Tsunade. Naruto would have to handle Jiraiya's feelings and his own respect for Tsunade in a new way. Also, his connection with his former self's students, like Konohamaru, would be different as he now has the role of a more senior and perhaps more carefree mentor like Jiraiya.
His friends might respect him more for having a useful new skill.
Well, it would be a huge blow to his friendships. Naruto's friends are drawn to his big heart and strong emotions. An emotionless Naruto would not respond in the same warm way. He might not share in their joys or sorrows. Sakura, for instance, would miss his determination and the way he used to encourage her. His friends would have to work hard to reach out to him, but they may also start to drift apart because the emotional connection is no longer there.
It would likely strain his relationship with Sasuke. Sasuke has his own complex history with Orochimaru, and if Naruto becomes a fan, Sasuke would be very confused and probably angry. He might see Naruto as betraying their shared values. As for his friends in Konoha, they would also be worried and try to talk Naruto out of it, which could lead to some arguments and a rift in their friendships.
It would have a huge negative impact. Naruto's friends have come to rely on his emotional support and his ability to inspire them. Without his emotions, he might not show the same enthusiasm in helping them. His friendship with Kakashi would also change as Kakashi has guided Naruto in part based on his emotions and his will to protect his friends. Naruto might seem distant and unresponsive, causing his friends to feel rejected.
Well, his friends might start to feel like he's drifting away. Since he's hiding his strength, he can't fully participate in training or battles as they expect. For example, Sakura might think Naruto is being lazy or not trying hard enough, which could create some tension between them.
His malnourishment could make his friends worry more about him. For example, Sakura might start to be more motherly towards Naruto, constantly trying to get him to eat proper meals. His relationship with Sasuke could also change as Sasuke might initially look down on Naruto for being weak because of the malnourishment, but then as he sees Naruto's determination to overcome it, he gains a new respect for him.
With Sasuke, it could either drive a wedge or bring them closer. If Sasuke blames himself for Naruto getting injured while protecting him, he might distance himself out of guilt. On the other hand, it could also make Sasuke realize how much Naruto means to him and he could become more committed to their friendship.
His apathy can strain his relationships. His friends might feel neglected. For instance, Sakura could be confused and hurt as Naruto no longer shows the same eagerness to be part of the team.
His illiteracy might make his friends initially frustrated. For instance, Sasuke, who is more studious, could be impatient with Naruto's inability to read important messages. But as they grow, they might become more understanding.
It could make some relationships stronger. His friends might be in awe of his new powers and look up to him even more. But it could also create some distance, as his new status might make others feel inferior.