It could be that Sakura and Ino are main characters in this fanfiction. They have a long - standing rivalry. Sakura might miss her chance to outdo Ino in something, like winning a medical ninjutsu competition or getting a certain mission. And this missed chance could lead to a rift in their relationship or make Sakura more determined to prove herself in other ways.
Sakura and Tsunade could be key characters. Tsunade being the Hokage and a great medical ninja could have offered Sakura a special training or a mission. But Sakura misses the chance due to her lack of confidence or some misunderstanding. This then affects her growth as a ninja and her relationship with Tsunade, who might be disappointed in her.
Sakura herself is obviously a main character. There could also be Naruto and Sasuke. Maybe Sakura misses her chance with Sasuke because she didn't speak up when she had the opportunity. Naruto might be involved as a friend who tries to encourage her but fails. Another character could be Kakashi, her sensei, who might have given her advice that she didn't follow, leading to her missing the chance.
Obviously, the main character is Sakura.
Perhaps Orochimaru. He might see Sakura's distraction from missing her chance as an opportunity to target Naruto or gain some advantage in his evil plans. He could manipulate the situation, making it even more difficult for Sakura to fix what she has missed.
Well, it could be about Sakura having a once - in - a - lifetime opportunity, like a chance to be with someone she loves or to achieve a great dream. But due to her hesitation or some unforeseen circumstances, she misses it. Maybe she was too shy to confess her feelings and the person she liked moved away. Or she didn't take a risk when a great opportunity for her ninja career presented itself and now she regrets it.
In this fanfiction, perhaps Sakura misses the chance to confess her true feelings to Naruto. Maybe she hesitates for too long, and by the time she decides to act, Naruto has already moved on with someone else, like Hinata.
Well, it could be about Sakura having a chance at something like a great opportunity in her career or a relationship with someone she really likes. But for some reason, she fails to take it. Maybe she was too scared or misjudged the situation.
One character could be Naruto. He might be Sakura's friend, but completely oblivious to her hidden pain. He's so focused on his own goals that he doesn't notice Sakura's struggle, which could add to her feelings of loneliness.
Sakura's friends like Naruto and Sasuke could be main characters. They might be the ones trying to find a way to save her. They could be using their skills and powers to look for a cure or a solution.
Sakura is the main focus. Alongside her, there could be a new character who she meets by chance and who somehow gets involved in her secret. This new character could be from a different place or group and has their own motives regarding Sakura's secret.
It could be Harry Potter himself having a chance encounter. Maybe he meets a new student who has some mysterious powers or a different view of the wizarding world. Another possibility is Hermione, who might come across a long - lost relative or an old wizard with ancient knowledge during a chance meeting.
Her closest friend might help her. Someone who really understands her and is willing to keep her secret. For example, Ino could be that friend. Ino has always been there for Sakura in the original story, so she could be the one to support Sakura during this difficult time.