A powerful dark wizard could be a great antagonist. He might want to use the Scarlet Baby's unique energy for his dark magic. He could send his minions, like flying monkeys or shadow serpents, to capture the baby.
Perhaps a group of hunters who have heard rumors about the Scarlet Baby being a valuable and magical being. They see it as a trophy and also believe that they can sell its magical parts for a great fortune. So they set out to hunt down the Wolf and the baby, using their advanced weapons and tracking skills.
It could be a dark wizard who has a vendetta against Erza and sees her son as a way to get revenge. This antagonist might try to corrupt the OC son or use him as a pawn in his evil plans.
An ancient sea demon that awakens during the Scarlet Tides. This demon was once sealed away but the power of the tides breaks the seal. It has a vendetta against the Fairy Tail guild because they were involved in its original sealing. So it sets out to destroy the guild and everything they hold dear.
Another vampire family that is jealous of the Mikaelson's power and influence. They see the baby as a threat to their future plans. They might try to kidnap the baby and use it as a bargaining chip to gain more power in the vampire world. They would be constantly plotting against the Mikaelsons to get their hands on the baby.
Danzo could be a great antagonist even when Naruto is a baby. He might see Naruto as a threat to his plans for Konoha's future and try to get rid of him secretly while making it look like an accident.
A rival alpha wolf could be the main antagonist. This rival might see Bella as a weakness in the alpha wolf's leadership or might want Bella for himself. He could constantly try to undermine the relationship between the alpha wolf and Bella and start battles with the alpha wolf's pack.
Perhaps it's a jealous ninja from another village. This ninja has always been envious of Naruto's power. So when he gets the chance, he uses a dark magic to turn Naruto into a wolf. His goal is to make Naruto weak and lose his status among the ninja community.
A human noble who doesn't approve of Ariel and Eric's union and especially doesn't like the idea of a half - human, half - mermaid baby. This noble could try to create problems for the family, like spreading false rumors or trying to get the baby separated from its parents. Another possibility is a sea monster that has been awakened by the birth of the baby, seeing it as an intrusion in its territory and trying to harm the baby and its parents.
An overzealous social worker who believes that Rizzoli and Isles are not fit to take care of the baby due to their dangerous jobs. This social worker could constantly be trying to take the baby away from them, creating a lot of conflict and drama in the fanfiction. Rizzoli and Isles would then have to prove that they can be great parents despite their demanding careers.
It could be an old enemy from their past, like a vengeful monster. Maybe a cyclops that they once defeated and now it wants to take revenge on them through their baby.
A group of rebels who have different ideas about how to handle the situation of the baby could also be the antagonists. They might think that Effie and Haymitch are too soft or too Capitol - influenced in their parenting of the baby. So they try to take the baby from them to raise it in their own way, believing it will be better for the future of the rebellion and the new society they are trying to build.