The relationship with Kakashi would be complex. Kakashi would have to be even more vigilant in training Naruto to control the Kyuubi's power. He might also be more protective of Naruto from those in the village who fear the Kyuubi. And Kakashi could try to teach Naruto how to use the Kyuubi's power in a more strategic and less destructive way.
With Sakura, she might be initially scared but then come to see Naruto as someone she needs to protect even more. She could develop new medical techniques specifically to help Naruto in case the Kyuubi's power ever goes out of control. And she would probably be more in awe of his strength and try to learn from him how to be stronger herself.
His relationship with Sasuke would likely be very different. Sasuke might be more suspicious of Naruto at first, seeing him as an unknown entity. But as they learn more about Naruto's new situation, they could develop a deeper bond based on Naruto's unique perspective.
If Naruto were not human, his relationships would likely be very different. For example, his relationship with Sasuke might be more strained. Sasuke, who is very focused on power and revenge, might see Naruto as a greater threat if he's not human. He could view Naruto's non - human abilities as something to envy or fear. With Sakura, she might be more hesitant around Naruto. Instead of her initial crush, she could be more cautious, not knowing what Naruto is truly capable of.
Naruto's relationship with Sasuke might be different. Instead of the rivalry based on power and recognition, Sasuke could be more jealous of Naruto's unique bond with the female Kyuubi. Naruto's friends like Sakura might also view him with a bit of awe and fear initially, since he is being raised by such a powerful and feared being. The village elders would likely be more distrustful of Naruto, thinking that the female Kyuubi is influencing him in a negative way.
His relationship with Sasuke would be different. Sasuke might view Naruto's connection with the Fem Kyuubi as a new source of power and be more wary or even jealous. But Naruto could use his new situation to try and bring Sasuke back to the right path earlier.
His relationship with Sasuke might become more of an equal partnership. With Naruto in his final form, Sasuke would recognize Naruto's new level of power and they could fight side by side against greater threats without the previous rivalry getting in the way.
With Sasuke, their rivalry might take on a new dimension. Sasuke could be both intrigued and threatened by Naruto's robotic abilities. He might see Naruto as an even greater obstacle to his own goals, or he could potentially try to use Naruto's robotic side for his own purposes.
With Sakura, she might be in awe of Naruto's new power. She could try to study his bloodline to see if it has any medical applications. Their friendship could grow stronger as Naruto uses his powers to protect her in new and unexpected ways, like creating a bloodline - based shield during a dangerous encounter.
Naruto's relationship with Kakashi would also change. Since Anko has her own way of doing things, Naruto might not be as receptive to Kakashi's laid - back teaching style at first. However, as he grows, he could come to appreciate both Anko's and Kakashi's approaches. And Kakashi might see Naruto as a more self - sufficient student compared to the original story, which could change their dynamic in terms of how much guidance Kakashi provides.
For Naruto's relationship with Kakashi - sensei, Kakashi would be very observant. He would notice the changes in Naruto immediately and try to guide him. Since Naruto is now a Youkai, his interactions with his peers would be different. Some might avoid him out of fear, like Hinata who would be very shy and worried about this new Naruto. But Naruto's core values would still be there. So over time, as he proves that he's still the same person deep down, his relationships could start to heal and grow in new ways, even if his appearance and some of his powers are now different.
Naruto's relationships would shift significantly. In Kirigakure, he'd have to form new friendships with local ninjas. These relationships would be based on different foundations compared to his Konoha friends. He might find it hard to trust at first. And his relationship with Kakashi would also change. Kakashi would probably be concerned about Naruto's new situation but also respect his decision to some extent. Naruto would have to start from scratch in building trust and camaraderie in Kirigakure.