Another antagonist could be a powerful ninja from another village who fears Naruto's wolf demon powers. They might start a war or plot assassinations in order to eliminate the perceived threat that Naruto poses to their village's safety and power.
Maybe there is an ancient wolf demon spirit that is corrupted and sees Naruto as a threat to its reign. This spirit would try to either kill Naruto or corrupt him further, causing chaos in the world.
It could be Orochimaru. He's always interested in strange and powerful forms, and Naruto's new wolf - bijuu form would be something he'd want to study or even control for his own evil purposes.
Perhaps the traditional enemies of Harry in the wizarding world would also become more hostile. They might be scared of his new powers and try to take him down before he becomes too powerful. And there could be some powerful oni demon lords who want to control Harry and use his unique situation for their own gain.
The Hidden Leaf Village elders could be antagonists. If Naruto turns dark, they might see him as a threat to their power and try to stop him. Their actions against Naruto could further fuel his descent into darkness.
The Hidden Leaf Village itself could become the main antagonist. Since Naruto turns evil, the village that once nurtured him would now be against him. The village elders and some of the ninja who oppose Naruto's new evil ways would be in conflict with him. For example, Kakashi might be forced to fight against Naruto to protect the village.
The Hidden Leaf Village elders could be main antagonists. If Naruto turns dark because he feels betrayed by the village, they would be the ones representing the establishment he is against. Their conservative and sometimes self - serving ways could be the catalyst for Naruto's transformation, and then they would be the ones trying to stop him as he becomes a threat to their power and the village's traditional order.
The main antagonists could be the ones who banished Naruto in the first place. Maybe it was a group of elders in the village who feared Naruto's power and wanted to get rid of him. They would see Naruto as a threat now that he is becoming the Onikage and would try to stop him from returning to the village or causing any changes.
The Akatsuki could also be the main antagonists. Since they are after the bijuu, they would surely target Naruto once he has this special relationship with them. They might try more elaborate schemes to capture the bijuu from Naruto and his 'harem' of sorts.
Perhaps it's a jealous ninja from another village. This ninja has always been envious of Naruto's power. So when he gets the chance, he uses a dark magic to turn Naruto into a wolf. His goal is to make Naruto weak and lose his status among the ninja community.
Another possibility is that a new, unknown group from outside the village emerges as the antagonists. They see Naruto as a threat to their own plans for domination or chaos, and they target the village under his leadership. This group could have unique powers and abilities that Naruto and the villagers have never faced before, making it a real test for Naruto as the Hokage.
In this fanfiction, the main antagonists could be a secret organization that has been studying the Six Paths powers in the shadows. They see Naruto as a threat to their plans of world domination. They could have their own powerful members with unique abilities that are specifically designed to counter Naruto's newfound powers as the Sage of the Six Paths. They might try to manipulate events and turn Naruto's friends against him to weaken his position.