One possible plotline could be that the sisters are on a quest. Maybe they are searching for a long - lost relative who is a powerful ninja in Konoha. Along the way, they have to overcome obstacles like rough terrains and unfriendly travelers. Once in Konoha, they start asking around and get involved in some ninja - related mysteries that might lead them to their relative.
Another plot could be that the sisters are running away from something in their own village, like a tyrannical leader. As they travel to Konoha, they learn about the values of the ninja world. In Konoha, they find a haven. One sister might fall in love with a ninja, which creates a whole new set of storylines, while the other sister discovers her own hidden ninja abilities and decides to train with the local ninja.
A popular one is 'Sisters in Konoha: A New Beginning'. The story begins with the sisters leaving their home due to a difficult situation. As they travel to Konoha, they encounter various threats like bandits. When they arrive in Konoha, they are taken in by a kind family. There, they slowly integrate into the community, with one sister starting to train in the ninja academy while the other helps out in local shops, and they both find their place in this new world.
One possible plotline could be that Naruto is somehow mind - controlled. Maybe an enemy uses a powerful genjutsu on him, making him see the Konoha 12 as threats to the village instead of comrades. This would lead to a tragic situation where Naruto, in his altered state of mind, attacks them.
One possible plotline could be that they leave to seek a new form of power. Maybe they've discovered a threat that the Hidden Leaf isn't aware of, and they believe they can find a solution outside. Another could be that they're on a journey of self - discovery. Sakura has always been in Sasuke's shadow to some extent, and this could be her chance to truly find herself while being with him. Also, perhaps they leave due to some political unrest in Konoha that they don't want to be a part of.
One possible plotline could be that Sakura leaves Konoha due to a personal quest for self - discovery. She might feel that she has outgrown the village or that there are things she can't achieve while staying there. For example, she could be in search of a new medical ninjutsu technique that can only be found in a far - off land. Along the way, Sasuke might cross her path, and they could either have a moment of reconciliation or further conflict depending on their respective states of mind.
One possible plotline could be Naruto leaving Konoha due to feeling out of place because of the harem situation. Maybe he's overwhelmed by the attention of multiple characters interested in him romantically and decides to seek solitude or a new path outside the village.
Perhaps Harry gets stuck in 1970 and has to find a way back. In the process, he discovers a long - lost magic that has been forgotten over time. He has to use this new - found magic in combination with his existing knowledge to build a time - travel device or find a magical artifact that can send him back to his own time.
Maybe Team 7 travels back in time to a period when a powerful and evil force first emerged. They then try to stop this force from growing in the first place. Along the way, they face challenges like not being recognized by the people of that time, and having to adapt to the older ways of doing things in the ninja world. They might also encounter versions of their own families or friends in the past and have to deal with the emotional turmoil of seeing them but not being able to fully interact as they are from different times.
One possible plotline could be that Naruto discovers a deep conspiracy within Konoha that makes him feel betrayed. For example, he might find out that some of the village elders have been using him all along as a tool to gain power. So in his rage, he decides to take revenge on the village. He could start by using his shadow clones to create chaos and disrupt the normal operations of Konoha.
One possible plotline could be that Naruto is somehow corrupted or misled. Maybe he discovers some dark secrets within Konoha that he believes can only be resolved by its destruction. As for the Alvarez Empire, they might see an opportunity to expand their influence in the chaos Naruto creates and form an uneasy alliance with him at first.
One possible plotline could be that Jon and Daenerys travel back in time to before the Night King was created. They might try to prevent the events that led to his creation. For example, they could stop the Children of the Forest from using dragonglass to create the first White Walker. This would change the entire future of Westeros and prevent the Great War against the dead.