Some of the more timid characters might be shy around Midoriya as a girl at first. For example, Mineta might be overly excited in a rather inappropriate way, which could lead to some conflict. However, the more mature characters like Iida would be very proper and offer practical help. They would see Midoriya as the same person inside, just in a different physical form, and would encourage her to keep up with her hero training.
The other characters' reactions would be diverse. Bakugo might initially be very confused and maybe even mock Midoriya a bit, but deep down he'd still see her as a rival. Uraraka would probably be very empathetic and quickly become a good friend to Midoriya in her new form, helping her with things like getting used to the new body. And All Might would be very supportive, seeing it as just another obstacle Midoriya has to overcome in her journey to become a great hero.
Some of the male characters might be a bit flustered around Naruto as a girl. For example, Kiba might act differently, not quite sure how to interact with her in this new form. Hinata, on the other hand, could become even more shy. She already had a crush on Naruto as a boy, and now with Naruto as a girl, her feelings could be even more complex. The Akatsuki members, if they were to encounter Naruto in her new form, might underestimate her at first. But Naruto, with her indomitable spirit, would soon show them that she's still a force to be reckoned with, regardless of gender. And the reactions of the characters would not only be about how they see Naruto, but also how Naruto's new form affects the power dynamics and relationships within the Naruto universe.
Well, one possible plot could be about Midoriya adjusting to life as a girl. She might face challenges in how society views her now. For example, her friends in the hero academy could initially be shocked but then gradually accept her new form. And she could use this new experience to better understand the female perspective in the hero world, which could in turn make her an even better hero.
Other characters' reactions can vary widely. Some of the more empathetic classmates, like Tsuyu, might offer words of comfort and stay by his side. Mineta might be a bit more cowardly, but still show some concern. The teachers, such as Aizawa, would take charge of the situation. Aizawa would ensure Midoriya gets proper medical attention and also start an investigation if the injury was due to foul play. His mother, if she were to find out, would be extremely worried and rush to be by his side as soon as possible.
Some characters might be really confused at first. For example, Scott would probably be very curious and try to figure out what happened to Nolan. Lydia, with her intelligence, might start researching immediately to find a way to turn him back. Stiles, on the other hand, would probably make a lot of jokes about Nolan's new cat - like behavior, like how he's always chasing after balls of yarn now.
Saber would probably be quite shocked at first. She's used to Shirou as a male, and this sudden change would make her re - evaluate their relationship. Rin might be more intrigued and try to figure out what caused the transformation. Archer would likely be a bit dismissive at first, but then realize that Shirou in this new form still has the same determination. Illya might find it really funny and tease Shirou a lot about it.
Midoriya's character development would be quite distinct. In his new form as a girl, he would have to re - evaluate his self - identity. He's always been a determined boy with a strong sense of justice. But as a girl, he might find that the world expects different things from him. This could lead to a struggle between his old self and the new self he's becoming. He might also develop a more nurturing side, which could enhance his hero capabilities in a different way. For instance, he could be better at calming down panicked civilians during a disaster. He would also have to deal with new forms of discrimination or assumptions based on his new gender.
Blake would probably be very shocked at first. Given their past relationship, she might feel a strange mix of emotions. She could be sympathetic towards Adam's situation, but also be cautious because of their history. Yang, on the other hand, might be more distrustful initially. She would see Adam as a potential threat still, even in his new form. Ruby might be the most open - minded, trying to see the good in Adam and offer help if needed.
Scott would probably be very protective. He'd feel responsible for taking care of Stiles and making sure he doesn't get into too much trouble. Lydia might be initially shocked but then use her intelligence to try and figure out how to reverse the situation. And Derek, well, he'd probably be a bit annoyed at first but would also end up being one of Stiles' protectors.
Sebastian, being the efficient butler, would likely immediately take charge of the situation. He would ensure the girl gets proper medical attention if possible. He might also start investigating the circumstances around the accident, suspecting foul play as is often the case in the 'Black Butler' world.
Dumbledore would be a key figure in the reactions. If he believed in Snape's innocence, he would try to find a way to free Snape while also not alienating Harry. He might start his own investigation to uncover the truth. The other Hogwarts teachers would be in shock. Some might believe Harry is right, especially those who have always been a bit suspicious of Snape, while others would be outraged and demand an explanation from Harry.