Some characters could become angry. They may feel that Harry was being rude or inconsiderate. For instance, if Harry was part of a team and left without saying goodbye, his teammates might be resentful and it could cause a rift in their relationships.
It might make them feel hurt or confused. If they were close to Harry, his sudden departure without a goodbye could make them wonder if they had done something wrong or if he didn't care about them as much as they thought.
The Weasley family as a whole would be affected. Molly Weasley, being a motherly figure, would be heartbroken for Ginny. Arthur might be more practical and try to offer advice to both Harry and Ginny. The other Weasley boys might have different reactions. George, still dealing with Fred's loss, might see Ginny's pain and be reminded of his own grief. Percy, who has always been a bit of an outsider, might try to use this as an opportunity to bond more with Ginny. As for the Hogwarts students, it could cause a stir among those who looked up to Harry and Ginny as a couple. Some might take sides, while others might be disappointed in the end of what they thought was a perfect relationship.
For Hermione and Ron, they might be shocked at first. But they would also understand Harry's reasons, especially if it was related to protecting them or the wizarding world. They would probably support Harry and help him deal with the aftermath, like dealing with the Death Eaters' retaliation.
Another reason could be that it was part of a plot device. The author wanted to create a sense of mystery or suspense. By not having Harry say goodbye, it makes the readers wonder what happened and what will happen next. It could also lead to future plot developments where his unexpected departure without a goodbye has consequences.
It can make other characters view their relationship as very exclusive. For example, Ron might feel left out sometimes if Harry is constantly overprotective of Hermione. This can create some tension between Ron and Harry in the fanfiction.
With the teachers, like Dumbledore, he might be treated differently. Dumbledore might see this transformation as an opportunity for Harry to learn new things about the wizarding world from a different perspective. And some of the more traditional teachers might have different expectations of Harry's behavior in class now that he is a girl.
His friends like Hermione and Ron would be deeply affected. They might feel abandoned at first. Hermione, being the logical one, would understand his reasons but still miss him terribly. Ron would probably be more vocal about his sadness and might even try to convince Harry to come back.
Some characters might find it odd or annoying at first. For instance, his friends like Ron and Hermione could be initially puzzled by this new behavior. Ron might make jokes about it, while Hermione could try to analyze it from a psychological or magical perspective.
His friends might feel sad and abandoned. For example, Hermione and Ron could be heartbroken at first, missing their best friend and wondering if they could have done something to make him stay.
Some characters might be shocked. For Hermione, who has always been a big advocate for the Hogwarts education system, she might be deeply offended and try to defend it vigorously. Ron, on the other hand, might be more conflicted. He might see some of Harry's points but also feel loyalty to the school they all grew up in.
For his friends, it could be a shock. They might feel abandoned and try to find him. Hermione, for example, would probably be worried sick and start looking for clues as to where he went. Ron might be more confused and angry at first, but then realize he needs to help find Harry. His family members would be devastated. His parents (if they are alive in the fanfiction) would be heartbroken, and his siblings might feel guilty or responsible.