Well, Bakugou might struggle to control One for All at first. It's a powerful quirk and he has his own explosive temper. He could accidentally cause a lot of destruction while trying to master it.
It's possible that Bakugou, with One for All, would start to develop new combat techniques. He'd combine his natural aggression and the new power. He might also face new enemies who are attracted to the power of One for All that he now possesses. This could put him in some really tough situations where he has to learn to use the quirk effectively and quickly to survive.
He could start to notice things from a different perspective. As a girl, Bakugou might become more aware of the way others perceive her appearance. She might also start to develop different interests, like taking more interest in fashion or something that she previously didn't care about. This could lead to some really interesting character development, especially if she still tries to hold on to her tough - guy (or now tough - girl) attitude.
He might become more responsible. Since One for All is such a significant power, he'd have to step up. He couldn't just be as reckless as he used to be.
One possible plot could be that Bakugou is in the middle of a battle with villains. He's being his usual brash self, charging ahead. Suddenly, a sniper from the villains' side takes aim and shoots him. His friends then have to rush to his aid and figure out how to get him medical help while still fending off the villains.
One possible plot could be that Uraraka struggles to control the new power of One for All at first. She might accidentally use it in inappropriate situations, like floating everything in her dorm room. But as she trains hard, she gradually masters it and uses it to save her friends in a big battle against a powerful villain.
Perhaps in the fanfiction, Aizawa gets One For All and decides to keep it a secret. He then starts training in isolation to master it. As he trains, he discovers new aspects of the power that are different from what previous users experienced, due to his own unique quirk and personality. He might use it to secretly protect his students from threats that are beyond the scope of his normal abilities.
There's also a possibility that it's an agent of a secret organization. This organization might be aiming to disrupt the hero society, and they see Bakugou as a key figure to target. So they send one of their best shooters to take him down.
She might discover long - lost magic. Since she has all the books, there could be some rare and forgotten spells or magical theories that she stumbles upon.
If it's a fanfiction about Class 1A meeting Bakugou's boyfriend, there could be a lot of comical moments. Maybe Mineta would try to be inappropriate and get scolded by Bakugou. The more responsible students like Iida might give Bakugou relationship advice. His boyfriend could be from another class or even another school. If he's from another school, Class 1A would be curious about the differences in their hero training. And Bakugou would have to balance his relationship with his training and his place in Class 1A.
One possible plot could be Naruto suddenly obtaining the One for All power. He might struggle at first to control it as it's a very different kind of power from the chakra he's used to. His friends would be both amazed and a bit worried. Naruto could then try to incorporate this new power into his fighting style, perhaps creating new jutsu that combine his ninja skills with the raw strength of One for All.
Perhaps she gets hurt while trying to protect someone she cares about. She could be shielding a friend from an attacker's blow, and in the process, take the brunt of the injury herself. This would then set up a story of her recovery and the revenge she might seek on the one who caused the harm.