Ron could be another character. Although he can be a bit hesitant at times, his loyalty to Harry and Hermione would make him follow them through the portal. And he might bring some unexpected humor to the new and strange situations they find themselves in.
One interesting plot could be that Harry discovers a hidden portal in Hogwarts that leads to a parallel magical world where the rules of magic are slightly different. He has to adapt quickly to survive and find his way back.
Twilight Sparkle is often very popular. Her intelligence and magic abilities make for great storylines, especially when she's dealing with the mysteries of a portal. Another popular one is Rainbow Dash, with her speed and bravery, she can have exciting adventures through the portals.
Chell is often a common supporting character. Since she had a lot of interactions with Wheatley in the game, it makes sense for her to be in the fanfictions. Another could be Cave Johnson, who might offer some sort of guidance or be a source of conflict for Wheatley in his human form. And GLaDOS can also be a supporting character, perhaps still having some sort of rivalry with Wheatley even when he's human.
In some Harry Potter portal fanfiction, the portal could be a gateway to a world where Muggle - born wizards are the ruling class. It would be fascinating to see how the pure - blood wizards react to this new power structure and how they adapt.
Ruby would be a great character to feature. Her energetic and adventurous nature would make her reactions to the strange Portal world really interesting. She'd probably be eager to explore and figure out how the portals work.
The main characters are the protagonist (the player - controlled character) and GLaDOS. The protagonist is the one who has to go through all the tests, while GLaDOS is the AI that controls the facility and creates the tests.
The main character is often an unnamed test subject.
In the story of Portal 2, Chell is the main character who has to navigate through the test chambers. Wheatley is an important character as he kicks off the adventure by waking Chell. He's a bit of a goofball. GLaDOS is another key figure. She was once an antagonist but her role becomes more complex as the story progresses. There are also some minor characters like the turrets which add to the overall atmosphere of the game.
The personality cores can be really interesting characters to include. For example, Wheatley's bumbling but well - meaning nature could contrast with Mel's more focused and determined personality. If you bring in the Adventure Core, it could lead Mel on some wild and wacky adventures within the facility, adding an element of unpredictability to the story.
Hermione is a very likely candidate. With her intelligence, she could easily start a business. For example, she might open a library - like establishment but with rare and restricted magical books that she has managed to collect through her research. She could charge a membership fee for witches and wizards to access these valuable resources.