The My Hero Academia show is pretty faithful to the manga. It keeps the main storyline intact and only makes small changes here and there to make it more suitable for the screen. Fans generally appreciate the adaptation's resemblance to the original manga.
Overall, the My Hero Academia show follows the manga quite closely. Some minor adjustments are made for better visual presentation or to fit the time constraints of the episodes. But the key story elements and character developments remain the same.
The show is mostly in line with the manga. There are some differences but they don't change the core plot.