Did Sig and Izumi ever meet Winry in the manga?

It's a complex plot point. Izumi's death is the result of a series of events and circumstances in the manga's storyline.

Yes, they do. It's a significant moment in the manga that shows the depth of their relationship.

Sure, Gon's encounter with Ging is a significant moment in the manga. It happens after a series of adventures and challenges that Gon goes through.

No, he doesn't. The manga doesn't have such a plotline.

Izumi Takatsuki first appeared in the first chapter of the Tokyo Ghoul manga.

Yes, they do. Their relationship progresses and they eventually tie the knot.

In certain comic arcs, Shang Chi crossed paths with the Mandarin. Their encounters often led to intense conflicts and strategic showdowns.

No, they never met in the original comics. Their storylines were separate.

Sesshomaru came across Rin when he was in a vulnerable state. Rin's innocent and caring nature drew them together. It was a pivotal moment that shaped their future interactions.

I'm not sure exactly, but you might be able to find the specific chapter by checking reliable manga forums or dedicated manga databases.