Comic book numbering is usually a sequential system. It starts from #1 and goes up as new issues are released. Sometimes there are reboots or special series that might have their own numbering systems.
Well, comic book numbering can be a bit complicated. It often follows a chronological order, but there are cases where publishers might do variant covers or special editions that could affect the numbering. Also, when a comic gets relaunched or has a new story arc, the numbering might restart or change in some way.