Spider-Man's spider-sense could be lost because of specific villains' plots or experiments gone wrong. Sometimes, it's a temporary effect caused by rare circumstances within the comic universe.
Well, there are various reasons for Spider-Man losing his spider-sense in the comics. It could be a result of a powerful enemy's special attack, or it might be a consequence of an internal conflict within his powers. Different comic arcs have presented different explanations for this occurrence.
In some comic storylines, Spider-Man lost his spider-sense due to powerful magic or advanced tech that disrupted his abilities.