The main difference is that tragic characters evoke sympathy and sadness as they struggle against overwhelming odds. Comic characters, instead, are designed to amuse and entertain us with their humorous behavior and circumstances. Tragic characters might have a fatal flaw that leads to their ruin, while comic characters' flaws are played for laughs.
Well, tragic characters usually face a lot of hardships and have a sad ending. Comic characters, on the other hand, bring more laughter and have lighter, more amusing storylines.
Tragic characters often have a series of misfortunes that lead to a downfall. Their flaws and circumstances contribute to a sense of hopelessness. Comic characters, though, have quirks and situations that make us laugh. They might have funny mishaps or a carefree attitude that creates humor.