Well, if Lee was never bitten, the entire course of the story could have changed drastically. Maybe he wouldn't have gained the powers or abilities that came with the bite, and his role and actions throughout the fanfiction would be completely different.
If Kenshin never made that vow, the character's development and his relationships with others might have been very different. He might not have had the same internal struggles and growth that make him so compelling.
He would have become incredibly powerful and likely been a major force in protecting the universe.
If Anakin hadn't turned, the Sith's plans might have been foiled. The balance of power would have remained with the Jedi, and galactic conflicts could have been avoided or resolved differently.
Well, the galaxy would have been a much more peaceful place. The Jedi Order might have remained strong, and there would likely have been no rise of the Empire.
Well, for one, the Lannister influence might not have been as strong. Also, the fate of Robert's children and the succession to the throne would likely have changed drastically.
Well, if Jon Snow never took the black, his path would have likely been very different. Maybe he would have stayed at Winterfell and had a greater role in the affairs of the North.
Well, it could have led to a completely different power dynamic in Westeros. Maybe Ned would have made different alliances or faced more challenges alone.
If Anakin never turned to the dark side in comics, the Jedi Order could have remained strong and continued to maintain balance. Maybe he would have become a great Jedi Master and trained many new padawans.
Anakin not going to the dark side could have prevented many conflicts. Maybe he would have found a way to peacefully resolve issues instead of resorting to violence. It would have changed the course of the entire Star Wars universe for the better.
If Vegito stayed fused, it's likely that he could have overpowered the villains with his combined strength and skills. There might have been fewer challenges and a quicker resolution to the conflict.