Perhaps the room is part of a psychological experiment or a virtual reality game where leaving is not allowed until certain conditions are met.
It could also be related to some sort of family or pure - blood related matter. Draco's family might have some connection to Hermione that he has just discovered, and he's trying to keep her in place to sort out the implications of this connection, which might involve protecting her from other dark forces or just making sure she doesn't interfere with his family's plans.
Maybe he leaves because of a conflict with the Hogwarts staff. If the new headmaster or some teachers start implementing rules that Harry believes are wrong or unfair, like restrictions on defensive magic classes, he might decide to leave in protest.
One reason could be a mission. Maybe he gets a top - secret mission that requires him to leave the village under Tsunade's leadership without her direct involvement. So he has to leave without much notice.
One possible reason could be to search for a powerful artifact. In many fanfictions, there are often hidden and powerful items that can change the fate of a village or even the whole ninja world. Naruto and Tsunade might leave Konoha to find such an item before their enemies do. This would be a dangerous mission, so they keep it a secret from the rest of the village to avoid panic.
One reason could be that the animal is a pest. For example, if it's a wild boar that has been invading people's farms and causing damage to their crops, the crowd might chase it to drive it away. Another possibility is that the animal is considered a danger. Like a rabid dog running around the village, so the people try to catch or kill it to protect themselves.
It could be due to something she ate. Maybe she had a lot of beans or some food that doesn't agree with her digestive system.
One possible reason could be to seek new adventures. They might feel they've reached a point in Fairy Tail where they've done all they can and want to explore new magic and challenges elsewhere. For example, they could have heard of a far - off land with a different type of magic that they are eager to learn about.
One possible reason could be illness. If a person is sick, like having a high fever or a bad cold, they can't go to school. Another reason might be family issues. For example, if there's an emergency at home that requires the person to stay and help. Also, it could be due to fear or bullying at school. If a student is constantly bullied, they may be too afraid to go to school.
Maybe it's to control population growth and maintain resources. The consequence could be a lot of frustration and social unrest.
Maybe it's a tragic ending. Suppose the story is about a couple in love. Due to some unforeseen circumstances like a war or a terminal illness, one of them passes away, leaving the other heartbroken. This would be a very sad but possible ending.