The four main characters of The Silence of the Lambs were: 1 Jason Bees (Jason Beihai)-One of the protagonists of this book, a psychiatrist, is accused of killing his wife and her lover. 2 Clarice Dufresne (Clarice Dufresne)-One of the protagonists of this book is an FBI agent responsible for investigating Jason Bees 'crimes. 3 Hannibal Lecter-The villain of the book is an FBI agent and an old friend of Jason Bees. 4 Jack Gyllenhaal (Jack Silver)-one of the supporting characters in the book, a banker and a mutual friend of Jason Bees and Clarice Dufresne. The best order to read The Silence of the Lambs is: The first volume of The Silence of the Lambs mainly tells the story of Jason Bees and his conflict with his wife and lover. The second volume of The Silence of the Lambs focuses on the investigation between Jason Bees and Clarice Dufresne and their interaction with Hannibal Lester. The third volume of The Silence of the Lambs focuses on the investigation between Jason Bees and Jack Gyllenhaal and their interaction with Hannibal Lester. The fourth volume of The Silence of the Lambs focuses on the investigation between Jason Bees and Clarice Dufresne and their interaction with Jack Gyllenhaal.