The most powerful villain in Marvel comics was Thanos. Thanos was a superhero with the power of the Infinity Gem. His goal was to obtain unlimited power and fulfill his wishes, including destroying half of his life. He achieved his goal by killing half of his life, which made him an extremely cruel and evil villain. His strength and ability far surpassed the other villains, including Titan Thanos and Shazan. In the Marvel Cinematic Universe, Thanos's image was further enhanced, his strength and abilities became more powerful, and his goal was more clearly achieved. Therefore, Thanos was still one of the most powerful villains in Marvel comics.