There was a certain relationship between the Nobel Prize in Literature and the best-selling literary works, but this relationship was not necessarily direct. The Nobel Prize in Literature was awarded to those who had outstanding achievements in the field of literature. Best-selling literary works were those that were widely spread and loved by readers. They were usually easy to understand and interesting, suitable for readers of all ages. The relationship between the Nobel Prize in Literature and the best-selling literary works was mainly manifested in the following aspects: 1. The Nobel Prize in Literature works usually have higher literary value and pay more attention to plot, character description, theme exploration, etc. The best-selling literary works pay more attention to entertainment and readable. The backgrounds and styles of the Nobel Prize in Literature works were often more diverse, while the best-selling literary works focused more on describing the common problems and contradictions of contemporary society and human nature. 3. The creation cycle of the Nobel Prize in Literature works is usually long and needs to go through many rounds of selection and review. Best-selling literary works pay more attention to time and market demand. Although there was a certain relationship between the Nobel Prize in Literature and the best-selling literary works, this did not mean that the Nobel Prize in Literature was necessarily a best-selling literary work, and the two should not be equated. Every work had its own unique value and meaning, and should be evaluated with different eyes.