This question was difficult to answer because the theme and setting of novels, anime, and movies were different, and the bloodlines that appeared in different works were also different. In some novels, powerful bloodlines usually referred to people with special abilities or special genes. For example, in some fantasy novels, powerful mages or warriors might have supernatural powers or special genes that allowed them to master magic faster than ordinary people or have higher combat abilities. In other works, strong bloodlines may refer to family or racial bloodlines. These bloodlines may have special abilities and advantages. For example, in some science fiction novels, certain races might have powerful technological abilities or powerful regenerative abilities that allowed them to gain an advantage in battle. Therefore, the strongest bloodline depended on the specific setting and theme of the novel, anime, or movie.